Low levels of glutathione – a master antioxidant in the body – could result in malfunction of the immune system. Recently reported evidence suggest that low levels of glutathione could be one of the major causes of the excessive inflammatory response linked to severe COVID-19.

Glutathione deficiency appears to be a crucial factor that contributes to  lung damage, acute respiratory distress syndrome, multi-organ failure, and death in COVID-19 patients.

When the antiviral activity of glutathione is also taken into account, individuals with glutathione deficiency seem to have a higher susceptibility to uncontrolled replication of SARS-CoV-2 virus causing an increasing viral load.

Increasing glutathione levels could reduce these COVID-19 complications.

So what is glutathione?

Glutathione is a powerful antioxidant found in every cell in the body. Without it they can’t survive. It has major effects on health at the molecular, cellular and organ levels. One unique thing about glutathione is that the body is able to make it in the liver, which is not true of most antioxidants.

Perhaps the best indicator of the importance of glutathione is that cellular levels are directly correlated with health and longevity. It works to detoxify the body, stimulate immune function, to produce natural killer cells, and to help balance inflammation (which can get out of control).


It is made of three linked amino acids, one of which, cysteine is a sulphur-containing amino acid. There are several specific nutrient deficiencies which can impair the body’s ability to produce glutathione. These are deficiencies that are commonly found in hospitalised COVID-19 patients:-

Vitamin D

Vitamin D  enhances the expression of genes related to glutathione – so the deficiency of this vitamin can cause low levels of glutathione.


Zinc influences the expression of glutamate-cysteine ligase, an enzyme involved in the synthesis of glutathione. So zinc deficiency can also cause low levels of glutathione.

Cysteine, glutamine and glycine

The amino acids, cysteine, glutamine and glycine are ‘building blocks’ used to produce glutathione in every cell in the body, including the brain. They have been termed non-essential amino acids because they can be synthesized in the body from other amino acids.

The ability to manufacture them as easily and abundantly as needed, however, is probably true only of people enjoying radiant good health. The enzymes required to synthesize them may be missing due to either metabolic error, gut dysbiosis or disease states.

The forgotten nutrient

Sulphur has been called “the forgotten nutrient”. It is, however, emerging as a key player in a process known as methylation.

We now know that, in methylation, the body uses sulphur to add methyl “donors” to activate various vital molecules in the body – proteins, DNA, neurotransmitters, etc.

Without successful ongoing methylation, DNA is left vulnerable to mutation, detoxification is impaired, the mitochondria (powerhouses) of our cells become exhausted, and we get fatigued and sick. The methylation cycle regulates sulphur metabolism in the body.  

This forgotten nutrient is enjoying a comeback. We’re rediscovering the health benefits of sulphur as science reveals it’s role in methylation.

The production of glutathione depends on sulphur!

This forgotten nutrient is enjoying a comeback. We’re rediscovering the health benefits of sulphur as science reveals it’s role in methylation.


Without magnesium, glutathione cannot be produced.

Magnesium is an absolute requirement for the proper functioning of an enzyme known as gamma-glutamyl transpeptidase (GGT), which plays a key role in the synthesis of glutathione.

I have gone into detail about all these nutrients on separate pages. Each one is vital to health and immunity – particularly during this pandemic.

A huge difference

However – when Covid strikes – a glutathione supplement can make a huge difference.

It’s important to buy a liposomal glutathione supplement – which is the most stable form.

You can buy this here

It’s expensive – and it doesn’t need to be used as a preventative, like the other nutrients mentioned here.

In stock

Don’t wait for infection to strike before ordering liposomal glutathione – have some in stock so that there’s no delay if  you find that you need it.

But ensure that you have adequate levels of the other nutrients too – they’re all critical for strong immunity.


Note: Glutathione is a very effective at detoxing the body. This can be uncomfortable if you try to do it too quickly. So don’t take more than the recommended dose.

You might even like to begin with a lower dose until you are confident that you are not experiencing too much detox discomfort (e.g. anxiety, irritability, headaches, insomnia….).

Note: A very few people don’t readily tolerate glutathione – particularly those who don’t tolerate sulphur-containing foods such as cabbage, kale or broccoli.

In any case, the aim in the longer-term should be to supply the body with all the nutrients it needs to make glutathione in the liver. But, for many people, liposmal glutathione can be an invaluable way to boost immunity quickly – when it is needed.


Note: – I will shortly be putting links here to the other nutrients mentioned on this page:-

Vitamin D


Cysteine, glutamine and glycine